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Daniele Dell'Orco

Bio

Daniele Dell’Orco is an Associate Professor of Biochemistry with a multidisciplinary background in biophysics, biochemistry, and molecular medicine. His research focuses on understanding the molecular mechanisms of photoreceptor function and degeneration in inherited retinal dystrophies (IRDs), integrating biochemical, biophysical, and computational approaches. Over the years, he has developed a strong expertise in the use of liposomes and nanodevices for the delivery of therapeutic proteins and biologics to the retina. His group demonstrated that lipid-based nanovesicles can successfully transport functional proteins into both inner and outer retinal layers, enabling targeted modulation of the phototransduction cascade. Additionally, he has explored the use of CaF₂ nanoparticles as protein carriers, revealing important structure–function relationships during delivery. His ongoing and past projects—funded by national and international agencies— highlight his devotion to the the field of translational approaches to retinal therapy. He actively collaborates with geneticists, neurobiologists, and ophthalmologists across Europe, ensuring a multidisciplinary and clinically relevant perspective.